Amyotrophic Lateral Sclerosis (ALS)
Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis. Gouel F*, Timmerman K, Gosset P, Raoul C, Dutheil M, Jonneaux A, Garçon G, Moreau C, Danel-Brunaud V, Duce J, Burnouf T, Devedjian JC, Devos D. Biomaterials, 2022.
Past and Future of Neurotrophic Growth Factors Therapies in ALS: From Single Neurotrophic Growth Factor to Stem Cells and Human Platelet Lysates. Gouel F, Rolland A-S, Devedjian JC, Burnouf T, Devos D. Frontiers in Neurology, 2019.
The protective effect of human platelet lysate in models of neurodegenerative disease: involvement of the Akt and MEK pathways. Gouel F, Do Van B, Chou ML, Jonneaux A, Moreau C, Bordet R, Burnouf T, Devedjian JC, Devos D*. Journal of Tissue Engineering and Regenerative Medicine, 2017.
Parkinson’s Disease
Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson’s disease models. Delila L, Nebie O, Le NTN, Timmerman K, Lee DY, Wu YW, Chou ML, Buée L, Chou SY, Blum D, Devos D*, Burnouf T*. Journal of Biomedical Science, 2024.
Neuroprotective activity of a virus-safe nanofiltered human platelet lysate depleted of extracellular vesicles in Parkinson’s disease and traumatic brain injury models. Delila L, Nebie O, Le N-T-N , Barro L, Chou M-L, Wu Y-W, Watanabe N, Takahara M, Buée L, Blum D, Devos D, Burnouf T*. Bioengineering & Translational Medicine, 2023.
Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson’s disease. Chou ML, Wu JW, Gouel F, Jonneaux A, Timmerman K, Renn TY, Laloux C, Chang HM, Lin LT, Devedjian JC, Devos D*, Burnouf T*. Biomaterials, 2017.
Traumatic Brain Injury
Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson’s disease models. Delila L, Nebie O, Le NTN, Timmerman K, Lee DY, Wu YW, Chou ML, Buée L, Chou SY, Blum D, Devos D*, Burnouf T*. Journal of Biomedical Science, 2024.
Human platelet lysate biotherapy for traumatic brain injury: pre-clinical assessment. Nebie O, Carvalho K, Barro L, Delila L, Faivre E, Renn TY, Chou ML, Wu YW, Nyam-Erdene A, Chou SY, Buée L, Hu CH, Peng CW, Devos D, Blum D, Burnouf T*. Brain, 2021.
Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro. Nebie O, Barro L, Wu YW, Knutson F, Buée L, Devos D, Peng CW, Blum D*, Burnouf T*. Platelets, 2021.
Neuroprotection
Characterization and Chromatographic Isolation of Platelet Extracellular Vesicles from Human Platelet Lysates for Applications in Neuroregenerative Medicine. Nyam-Erdene A, Nebie O, Delila L, Buée L, Devos D, Chou S-Y, Blum D, Burnouf T*. ACS Biomaterials Science & Engineering, 2021.
Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for dedicated clinical uses. Delila L, Wu Y-W, Nebie O, Widyaningrum R, Chou M-L, Devos D, Burnouf T*. Platelets, 2021.
The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates. Nebie O, Devos D, Vingtdeux V, Barro L, Devedjian JC, Jonneaux A, Chou ML, Bordet R, Buée L, Knutson F, Blum D*, Burnouf T*. Journal of Biomedical Science, 2019.
Mitochondria protection
Human Platelet-derived Lysates and Extracellular Vesicles Restore Mitochondrial Function and Redox Balance in Neuronal Models. Gupta K, Delila L, Blum D, Pandith A, Burnouf T*. Biorkiv, 2025.
Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy? Yeh HC, Gupta K, Lu YH, Srinivasan A, Delila L, Yen NTH, Nyam-Erdene A, Burnouf T*. ACS Biomaterials Science & Engineering, 2025.
Hippocampal Neurogenesis
Platelet concentrate-derived extracellular vesicles promote adult hippocampal neurogenesis. NyamErdene A, Le NTN, Nebie O, Faivre E, Delila L, Chou ML, Lowe JR, Bantubungi K, Buée L, Walker TL, Blum D, Burnouf T*. Biomaterials, 2025.
Proteomics of Human Platelet Lysates and insights from animal studies on platelet proteins diffusion to hippocampus upon intranasal administration. Le NTN, Han CL, Delila L, Nebie O, Chien HT, Wu YW, Buée L, Blum D*, Burnouf T*. APL Bioengineering, 2024.
Review
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery. Burnouf T,* Chou ML, Lundy DJ, Chuang EY, Tseng CL, Goubran H. Journal of Biomedical Science, 2023.
The multifaceted role of platelets in mediating brain function. Burnouf T*, Walker T*. Blood, 2022.
Can the administration of platelet lysates to the brain help treat neurological disorders? Nebie O, Buée L, Blum D*, Burnouf T*. Cellular & Molecular Life Sciences, 2022.
